Pathophysiology of Hypertension
Year: 2009
Type: book-chapter
Abstract: Blood pressure can fundamentally be viewed as a function of cardiac output (CO) and systemic vascular resistance. Cardiac output depends on cardiac stroke volume and heart rate. Stroke volume in turn depends on myocontractility and preload. Systemic vascular resistance is dependent on vessel elasticity, myocontractility and afterload. Recent research has begun to unravel relationships at the cellular and molecular levels that exert important effects on blood pressure. The endothelium, intima, vascular smooth muscle and extracellular matrix interact with each other and with vasomotor, growth factors, transcriptional, hormonal and neuronal factors that affect signal transduction, gene transcription, ion transport, tissue remodeling and cellular response, all in the context of the patient’s genetic background. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Source: Springer eBooks
Authors: Ikuyo Yamaguchi, Joseph T. Flynn
Institutions: Seattle Children's Hospital, University of Washington
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W1571060185