Work

MiR-107 is Reduced in Alzheimer's Disease Brain Neocortex: Validation Study

Year: 2010

Type: article

Abstract: MiR-107 is a microRNA (miRNA) that we reported previously to have decreased expression in the temporal cortical gray matter early in the progression of Alzheimer's disease (AD). Here we study a new group of well-characterized human temporal cortex samples (N=19). MiR-107 expression was assessed, normalized to miR-124 and let-7a. Correlation was observed between decreased miR-107 expression and increased neuritic plaque counts (P< 0.05) and neurofibrillary tangle counts (P< 0.02) in adjacent brain tissue. Adjusted miR-107 and BACE1 mRNA levels tended to correlate negatively (trend with regression P< 0.07). In sum, miR-107 expression tends to be lower relative to other miRNAs as AD progresses.

Source: Journal of Alzheimer s Disease

DOI: 10.3233/jad-2010-091603

Authors: Peter T. Nelson, Wang-Xia Wang

Institution: University of Kentucky

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: University of Kentucky, National Institutes of Health, National Institute on Aging, National Institute of Neurological Disorders and Stroke