Work

Commentary on IL ‐1β associations with posttraumatic epilepsy development: A genetics and biomarker cohort study

Year: 2015

Type: editorial

Abstract: Human posttraumatic epilepsy (PTE), the most common acquired epilepsy in teenagers and young adults, 1 is an unfortunate natural experiment that may provide insight into epileptogenesis and antiepileptogenic interventions.In PTE, epilepsy develops weeks to months after traumatic brain injury (TBI), and often in a previously nonepileptic and otherwise healthy brain.Particularly in severe TBI, the injury timing is well-documented, and by necessity for critical care, the patients are closely monitored with access to imaging, electrophysiologic, blood, and cerebrospinal fluid (CSF) biomarkers.Yet, the neurobiology of events that take place in the time between TBI and the first seizure of PTE, remains incompletely understood.This gap in knowledge

Source: Epilepsia

DOI: 10.1111/epi.13049

Author: Alexander Rotenberg

Institutions: Boston Children's Hospital, Harvard University

Language: English

Topic: Epilepsy research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: U.S. Department of Defense, Boston Children's Hospital, National Institutes of Health, National Institute of Neurological Disorders and Stroke