Year: 2004
Type: dissertation
Abstract: ACC adrenocortical carcinoma ACTH adrenocorticotropin ACTHR adrenocorticotropin receptor ACH adrenal hypoplasia congenita (Bu) 2 cAMP dibutyryl cyclic adenocine 3´5´-monophosphate cAMP cyclic adenocine 3´5´-monophosphate cDNA complementary deoxyribonucleic acid CBP CREB-binding protein CE extreme dilution strain of mice DAX-1 dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1 DBA dilute brown strain of mice DHEA dehydroepiandrosterone DHEAS dehydroepiandrosterone sulphate E embryonic day ES embryonic stem FCS fetal calf serum FGF fibroblast growth factor FOG Friend of GATA FSH follicle stimulating hormone hCG human chorionic gonadotropin IGF insulin-like growth factor Inhα/SV40Tag inhibin α-subunit promoter/simian virus 40 transforming antigen LH luteinizing hormone LHβ luteinizing hormone β subunit LHR luteinizing hormone receptor MIS Müllerian inhibiting substance mRNA messenger ribonucleic acid P postnatal day P450c17 cytochrome P450 17α-hydroxylase/17,20-lyase P450scc cytochrome P450 side-chain cleavage enzyme PBS phosphate-buffered saline PFA paraformaldehyde PKA protein kinase A RT-PCR reverse-transcriptase polymerase chain reaction SF-1 steroidogenic factor 1 StAR steroidogenic acute regulatory protein SULT2A1 dehydroepiandrosterone-sulfotransferase TGF transforming growth factor Wnt-4 wingless-related mouse mammary tumor virus integration site wt wild type WT-1 Wilm's tumor gene-1abnormalities in the chromosomal 11p15.5 locus, are frequently found in adrenocortical carcinoma cells, the molecular events leading to adrenocortical tumorigenesis are still mainly unknown.Tissue development and the maintenance of a differentiated cell type with specific properties require activation of a well-balanced subset of genes.This allows tissue diversity and adaptation to changing conditions.Appropriate timing of gene expression is also critical for accomplishing crucial steps during development.The expression of genes is regulated primarily by transcription factors, which bind to the regulatory sequences of DNA upstream of the transcription initiation site.Transcription factors are numerous and have functions in conducting and modulating all cellular events.They are under intensive study in order to understand the multiplicity of living organisms, tissue diversity and development, and ultimately the etiology of various human diseases.The transcription factors of the GATA family have roles in the development and function of several organs.They are essential e.g. for the proper development of hematopoietic cells, the heart and central nervous system.In these organ systems GATA proteins are thought to have regulative tasks during differentiation and proliferation.In adult tissues they act during adaptive reactions to mechanical or hormonal stimuli, together with the maintenance of homeostasis.Several target genes for GATA proteins have already been identified.The disrupted function of GATA transcription factors have been linked to a wide spectrum of human disease, from rare congenital diseases and malignancies to common diseases such as asthma and obesity.
Source: Työväentutkimus Vuosikirja
Author: Sanne Kiiveri
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: Helsingin Yliopisto
OpenAlex ID: W1572348401