Year: 2000
Type: article
Abstract: After activation CD4(+) helper T cells differentiate into T-helper (Th) 1 or Th2 effector cells. These two subsets are characterized by their distinct cytokine expression pattern and the immune function they mediate. Over the past years, a number of factors have been identified to affect helper T cell lineage determination, including antigen receptor, coreceptors and, most importantly, cytokine environment. In this review, we also summarize recent advancement in understanding of transcriptional and signaling regulation of the differentiation process. This knowledge will become important in the future to develop means in treating immune disorders.
Source: Arthritis Research
DOI: 10.1186/ar85
Authors: Chen Dong, Richard A Flavell
Institutions: Howard Hughes Medical Institute, Yale University
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: diamond
Funder: Howard Hughes Medical Institute
OpenAlex ID: W1573032931