Studies on the Drugs for Peptic Ulcer. A Reliable Method for Producing Stress Ulcer in Rats.
Year: 1964
Type: article
Abstract: A simple and reliable method for production of gastric ulcer on rats by stress was described. Rats fixed on boards were immersed in water of 25°to the depth of xiphoide. After 20 hours, marked gastric erosions were found in the glandular portion of the stomach. This stress is more favourable than other stresses as cold, restraint, or emotional stress by stress box in view of incidence and mortality. Anticholinergics or central depressants effectively inhibited the ulceration and combination of both drugs suppressed it more effectively than single administration of each drug.
DOI: 10.1248/cpb.12.465
Authors: Keijiro Takagi, Yutaka Kasuya, Kazuo Watanabe
Institution: The University of Tokyo
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W1573533055