Work

Use of live cold-adapted influenza A H1N1 and H3N2 virus vaccines in seropositive adults

Year: 1990

Type: article

Abstract: To investigate the immunogenicity and protective efficacy of cold-adapted influenza vaccine in individuals with underlying immunity to influenza A virus, we administered cold-adapted H1N1 and H3N2 vaccines to adults with prevaccination serum hemagglutination inhibition antibody titers of 1:16 or more and challenged them 1 month afterwards with homologous wild-type influenza A virus. Both cold-adapted vaccines were immunogenic in seropositive adults. In addition, individuals receiving cold-adapted vaccines had lower rates of virus shedding and illness following challenge with wild-type influenza virus than did unvaccinated seropositive volunteers.

Source: Journal of Clinical Microbiology

DOI: 10.1128/jcm.28.3.596-599.1990

Authors: J J Treanor, F K Roth, R F Betts

Institutions: University of Rochester Medicine, University of Rochester

Language: English

Topic: Influenza Virus Research Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Aging, National Institute of Allergy and Infectious Diseases