Aminophylline, Adenosine Antagonist Attenuates Glycerol-Induced Acute Renal Failure in Rats
Year: 2014
Type: article
Abstract: we investigate the effect of Aminophylline against acute renal failure (ARF) in female Albino Wister rats. ARF was produced by glycerol as a simple method for induction ARF so this achieved by injection of glycerol as single dose (10ml/kg, 50%V/V with tap water, IM) in rats which were restricted to drinking water for 24 hours. Aminophylline (5mg/rat I.P) was administered as a single dose at (60min.'s) before ARF. The blood urea nitrogen ( BUN ) and serum creatinine ( Scr ) concentrations were markedly elevated in glycerol-ARF group on the 1 st day and 3 rd day, but the elevation was significantly suppressed by Aminophylline. Also Aminophylline markedly attenuated the severe impairment of creatinine clearance ( Crcl ) caused by glycerol. Conclusion: These findings suggest that Aminophylline can protect the renal damage caused by glycerol. Key words : ARF, glycerol, Aminophylline.
Language: English
Topic: Acute Kidney Injury Research
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1573913157