The development of antimicrobial biomaterial surfaces
Year: 2001
Type: dissertation
Abstract: Summary One of the major drawbacks in the use of biomedical materials is the occurrence ofbiomaterial-centered infections. After implantation, the host interacts with a biomaterial byforming a conditioning film on its surface and an immune reaction towards the foreignmaterial. When microorganisms reach a biomaterial surface they can adhere to it. Adhesion ofmicroorganisms to an implant is mediated by their physico-chemical surface properties andthe properties of the biomaterial surface itself. Subsequent surface growth of themicroorganisms will lead to a mature biofilm and infection, which is difficult to eradicate byantibiotics. Chapter 1 gives an overview of the mechanisms involved in biomaterial-centeredinfection and the possible strategies to prevent these infections. Chapter 2 describes the parallel plate flow chamber system. With this system thedifferent steps in biofilm formation, i.e. conditioning film formation, initial bacterialadhesion, bacterial surface growth and bacterial detachment can be modeled and monitored
Author: Bart Gottenbos
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1574715974