The relation of deoxyribonuclease inhibitor levels to the occurrence of antinuclear antibodies in NZB-NZW mice.
Year: 1972
Type: article
Abstract: The level of heat-labile DNase 1 inhibitor in the serum of NZB/NZW F(1) mice has been found to be significantly higher in animals having antinuclear antibodies. The inhibitor level in the hybrid mice without antinuclear antibodies was not significantly different from that found in control groups of NZB, NZW and BALB/c mice. These findings are discussed in the light of the hypothesis that excessive inhibition of DNase may play a part in rendering DNA nucleoproteins antigenic.
Source: PubMed
Authors: K Hadjiyannaki, P J Lachmann
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1575638756