NOS İnhibisyonu Aracılı Hipertansiyon: Sıçanlarda Sabit ve Kademeli doz L-NNA Uygulamalarının Karşılaştırılması
Year: 2007
Type: article
Abstract: Objective: Chronic NOS inhibition-induced hypertension model is used commonly in essential hypertension researches. All these studies investigated using a stable doses of NOS inhibitor agents over experimental progress. But, it is decreased gradually synthesis and/or release of NO in essential hypertension. To better mimic essential hypertension, the doses of L-NNA (a NOS inhibitor) was administrated gradually increasing and was compared group of stable dose. Material and Method: Wistar rats were divided into 3 groups. Control group was done any administration. Second group took the stable concentration of L-NNA over 3 weeks and third group took gradually increasing concentration of L-NNA for 3 weeks. Blood pressure and heart rate are measured by tail-cuff method. Plasma nitrite/nitrate levels and kidney/body weigth ratios were also compared. Results: In the stable dose administrated group, heart rates decreased while the blood pressure increased. On the other hand, in the gradually increasing doses of L-NNA administrated group, heart rates did not change despite the increasing blood pressure. Plasma nitrite/nitrate levels decreased significantly but there was any change in kidney/body weight indexes in groups. Conclusion: It is suggested that is associated more gradually NOS inhibition than stable NOS inhibition with essential hypertension. ©2007, Fırat Uiversity, Medical Faculty
Source: DergiPark (Istanbul University)
Authors: Süleyman Oktar, Engin Yılmaz, Engin Şahna, Hakkı Engin Aksulu
Language: Turkish
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1577578708