Regulation of Sodium Transport in the Proximal Tubule by Endothelin
Year: 2011
Type: book-chapter
Abstract: Human essential hypertension and rodent genetic hypertension are associated with increased sodium transport in the renal proximal tubule and medullary thick ascending limb of Henle. The proximal tubule, which secretes endothelin (ET), expresses the ET(B) receptor. Low (nM) concentrations of ET, via the ET(B) receptor, inhibit sodium and water transport and ATP-driven drug secretion in the proximal tubule. In contrast, very low (pM) and high nM concentrations of ET increase renal proximal sodium transport, but the receptor involved remains to be determined. The natriuretic effect of ET(B) receptor stimulation is impaired in spontaneously hypertensive rats, due in part to a defective interaction with D(3) dopamine and angiotensin II type 1 receptors. Impaired ET(B) receptor function in the renal proximal tubule may be important in the pathogenesis of genetic hypertension.
Source: Contributions to nephrology
DOI: 10.1159/000328684
Authors: Ye Zhang, Pedro A. Jose, Chunyu Zeng
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: National Natural Science Foundation of China, Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission, National Institutes of Health, National Institutes of Natural Sciences, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases
Awards: G1064172643, G1403022750, G1783080005, Molecular Mechanisms in Salt Sensitivity of Blood Pressure, G2941462882, Renal dopamine-1 receptor defect in hypertension, G572264085, G7370547714, Oxidative Stress In The Kidney In Hypertension, Renal Dopamine Receptor and Regulation, GRK4 & Development of Salt Sensitivity
OpenAlex ID: W1577706132