Work

Memory and neurogenesis in aging and Alzheimer's disease.

Year: 2010

Type: article

Abstract: A possible link between a deficient neurogenesis at the dentate gyrus, and the loss of memory found in Alzheimer's disease patients is discussed. First is indicated that Alzheimer disease is a memory disorder. Since adult neurogenesis at the dentate gyrus plays a role in declarative memory, a brief comment on the structure and function of dentate gyrus has been included. At molecular level, we have discussed the function of the enzyme GSK3 on the development of neurogenesis at the subgranular zone of the dentate gyrus. Finally, we have indicated that in Alzheimer disease there is an increase in GSK3 activity. This increase could impair the neurogenesis process and it could result in the memory deficit found in Alzheimer patients.

Source: Europe PMC (PubMed Central)

Authors: Jesus Avila, Ricardo Insausti, Joaquin Del Rio

Institutions: Consejo Superior de Investigaciones Científicas, Biomedical Research Networking Center on Neurodegenerative Diseases, Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid

Language: English

Topic: Neurogenesis and neuroplasticity mechanisms

Subfield: Developmental Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1577872131

FWCI: 0.286

Cites: 59

Cited by: 13

Related to: 10