The Relationship between Tumour Necrosis Factor -Alpha and Zinc/Copper Ratio in Iraqi Patients with Allergic Rhinitis
Year: 2014
Type: article
Study design: Observational Study
Abstract: Abs tract- Background: Aller gi rhinitis(AR) is a significant cause of widespread morbidity, high medical treatment costs,reduced work productivity,lowquality of life and can be associated with conditions such as fatigue, headache, cognitive impairment, and sleep disturbance. Aim o f the study: To fin d out the relation between tumour necrosis factor alpha (TNF-α) and Zn/Cu ratioin the patients with mild or moderate/severe cases. Patients and Methods: Ninety subject were enrolled in this study .Fifty patients with AR were subdivided into two groups i.e. mild (comprising 20 patients) with AR , moderate/ severe (comprising 30 patients) with AR . Forty subjects who are apparently healthy were taken as a control group. Serum TNF-α was determind by using enzyme- linked immunosorbent assay (ELISA). Zn and Cu were determined by using colorimetric method. Res ults: Seru m levels of TNF-α was significantly higher in mild and moderate/severe groups compared with control group (p<0.01).A significant positive correlation between TNF-α and copper. A significant negative correlation between TNF-α and zinc in AR patients in mild and moderate/severe cases. Con clusion: Zn/ Cu ratio affect TNF-α level in patients with AR.
Language: English
Subfield: Immunology and Allergy
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W1578527458