Experimental Studies on Morphological Changes of the Epididymis and Testis in Neonatally Estrogenized Mice Revisited
Year: 2007
Type: article
Abstract: Our primary concern in this review is to give possible explanations and pose new questions on the phenomena\nconcerning effects of neonatal estrogen exposure on the development and functions of reproductive organs and immune\nmechanisms particularly in male animals, in the light of new findings and cencepts. At first, our own experimental results\non the pathological changes in the epididymis and testis in neonatally estrogenized mice have been presented. The results\nof our first experiment showed that neonatal single injection of 10 flg of estradiol benzoate induced marked inflammatory\nchanges in the epididymis and testis, in which the initial pathological change occurred concomitantly with the appearance\nof sperms in the epididymal duct. The second experiment showed that such epididymo-testicular changes did not occur\nwhen the testis was removed or neonatal estrogen was followed by testosterone. From these results, a possibility was\nsuggested that a hormone-related autoimmune mechanism might participate in such changes. Relating to these, various\nreports concerning effects of neonatal estrogen treatment, either alone or with concommitent treatment with androgen.\non the development and functions of reproductive organs and immune mechanisms in the adolescent or adult have been\nreviewed. In addition, advances in the related areas, such as estrogen-related mechanisms in the development and\nfunctions of reproductive organs and immune mechanisms including autoimmune disease mechanisms. gender differences\nand the role of CD25+ CD4+ T lymphocytes have also been reviewed briefly.
Authors: Takashi Kachi, Hitomi Kachi
Institution: Hirosaki University
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W561256060