Work

Specific interactions between transcription factors and the promoter-regulatory region of the human cytomegalovirus major immediate-early gene

Year: 1988

Type: article

Abstract: Repeat sequence motifs as well as unique sequences between nucleotides -150 and -22 of the human cytomegalovirus immediate-early 1 gene interact in vitro with nuclear proteins. We show that a transcriptional element between nucleotides -91 and -65 stimulated promoter activity in vivo and in vitro by binding specific cellular transcription factors. Finally, a common sequence motif, (T)TGG/AC, present in 15 of the determined binding sites suggests a particular class of nuclear factors associated with the immediate-early 1 gene.

Source: Journal of Virology

DOI: 10.1128/jvi.62.3.1076-1079.1988

Authors: P Ghazal, H Lubon, L Hennighausen

Institutions: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases

Language: English

Topic: Cytomegalovirus and herpesvirus research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1579186703

FWCI: 8.347

Cites: 13

Cited by: 44

Related to: 10