Work

Liposome‐associated retinoic acid

Year: 1990

Type: article

Abstract: The activity of liposome-associated retinoic acid was analyzed on in vitro cultured tumor cell lines and compared to the antiproliferative effects of free retinoic acid. It was found that liposome-associated retinoic acid is about 300 times more active than free retinoic acid in inhibiting in vitro cell growth of leukemic and melanoma cell lines. An increased activity of retinoic acid (10-20 times) was also obtained after premixing of this compound with empty liposomes, demonstrating that the retinoic acid efficiently interacts with liposomes which may facilitate solubility and cell uptake of retinoids.

Source: FEBS Letters

DOI: 10.1016/0014-5793(90)80030-m

Authors: Claudio Nastruzzi, Peter Walde, Enea Menegatti, Roberto Gambari

Institutions: ETH Zurich, Institute of Polymers, University of Ferrara

Language: English

Topic: Retinoids in leukemia and cellular processes

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Regione del Veneto