Generation of free radicals from metronidazole and other nitroimidazoles by Tritrichomonas foetus.
Year: 1983
Type: article
Abstract: Metronidazole, ronidazole, secnidazole, benznidazole, and misonidazole are reduced by intact Tritrichomonas foetus cells to nitro anion radicals that can be detected by electron spin resonance spectroscopy. This activity appears to be related to the cellular content of reducing substrates, since nitro anion radical formation is stimulated in the presence of glucose and pyruvate. The nitro anion radicals could not be detected under aerobic conditions. Anaerobic homogenates of T. foetus also reduce metronidazole to the nitro anion radical when pyruvate, NADH, or NADPH is added as the ultimate source of reducing equivalents. Free radical formation may be the basic cause of nitroimidazole toxicity in trichomonads.
Source: Journal of Biological Chemistry
Authors: S N Moreno, R P Mason, R P Muniz, F S Cruz, R Docampo
Language: English
Subfield: Toxicology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,430
OpenAlex ID: W1580909913