Year: 2015
Type: dissertation
Abstract: Patients receiving long-term corticosteroid treatment may develop adrenal insufficiency (AI) with failure of an adequate cortisol surge during stress, potentially resulting in serious illness and death.There is growing concern about inhaled corticosteroids, used in the treatment of asthma, causing AI.List of abbreviated terms 11-HSD-2 -11-hydroxysteroid dehydrogenase type 2 Ab -antibody ACTH -adrenocorticotropic hormone ACTH(1-24) -Synacthen ACTH(1-39) -endogenous ACTH ADR -adverse drug reaction Ag -antigen Ag* -radiolabelled antigen AI -adrenal insufficiency AIDS -acquired immunodeficiency syndrome AUC -area under the curve AVP -arginine vasopressin BDP -beclomethasone dipropionate BNFc -British National Formulary for Children BMI -body mass index (kg/m 2 ) BMS -biomedical Scientist BSA -body surface area (m 2 ) BTS -British Thoracic Society CAH -congenital adrenal hyperplasia cAMP -cyclic adenosine monophosphate (second messenger) CAR -cortisol awakening response CBG -corticosteroid-binding globulin CCRF -children's clinical research facility (based at Sheffield Children's Hospital) CIAs -chemiluminescent immunometric assays CL -clearance Cmax -maximum concentration of a drug in plasma CNS -central nervous system CRH -corticotrophin-releasing hormone CRH-R1 -corticotropin-releasing hormone receptor-1 CRH-R2 -corticotropin-releasing hormone receptor-2 CTIMP -(clinical trial of investigational medicinal product) CV -coefficient of variation
Author: Charlotte Elder
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1581900580