Work

A Role for Bax in the Regulation of Apoptosis in Mouse Mast Cells

Year: 2000

Type: article

Abstract: Bax, a death promoting member of the Bcl-2-related family of proteins, is required for the induction of apoptosis in several cell lineages, including thymocytes, B cells, and certain neurons; by contrast, Bcl-2 promotes cell survival by suppressing apoptosis via an interaction with Bax (Knudson & Korsmeyer 1997). To determine whether Bax or Bcl-2 might also be involved in the regulation of mast cell (MC) populations in vivo, the numbers of MC in the stomach and skin of Bax-deficient (Bax–/–) mice (Knudson et al.

Source: Journal of Investigative Dermatology

DOI: 10.1046/j.1523-1747.2000.00005.x

Authors: Marcus Maurer, Mindy Tsai, Martin Metz, Sue Fish, Stanley J. Korsmeyer, Stephen J. Galli