Investigating the effects of hydro-alcoholic extract of Launaea acanthodes on the serum levels of glucose, insulin, lipids and lipoproteins in stereptozotocin induced type I diabetic rats
Year: 2012
Type: article
Abstract: Background: Launaea acanthodes is used as a common medicinal plant in central regions of Iran. To investigate the probable hypoglycemic activity of hydro-alcoholic extract of L. acanthodes as well as its effects on serum level of insulin and biochemical factors in normal and hyperglycemic rats, the present study was carried out. Materials and Methods: In this experimental study 24 male albino Wistar rats, weighting 250300 g were randomly allocated into four groups (n=6); control, type 1 diabetic rats (STZ; 55 mg/kg), type 1 diabetic rats treated by subcutaneous injection of 5 IU/kg insulin (STZ+insulin) and type 1 diabetic rats treated by injection (i.p) of 150 mg/kg hydro-alcoholic extract of L. Acanthodes (STZ+extract). The injection of insulin and extract were done every day from day 1 to day 21 of experiment. After that, all animals were kept up to day 30. Blood serum were collected and analyzed for the levels of glucose and biochemical factors (cholesterol, triglyceride, LDL and HDL) measurements, in the 15 th and 30 th day of experiment. Results: The results showed significant decrease (p<0.001) in glucose level and significant increase (p<0.05) in insulin level in STZ+extract group, when compared with other hyperglycemic groups in 30 th day of experiment. Conclusion: These results indicate that the hydro- alcoholic extract of L.acanthodes could be effective in the treatment of diabetes. It can be concluded that extract administration somehow induce insulin secretion probably through stimulation of remaining β cells or their hyperplasia in Langerhans islets. This effect can also be referred to flavonoides constituent and antioxidant property of extract, too.
Source: مجله دانشگاه علوم پزشکی اراک
Institution: Ferdowsi University of Mashhad
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W1582780582