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Rigid Orthogonal Bis-TEMPO Biradicals with Improved Solubility for Dynamic Nuclear Polarization

Year: 2012
Type: article
Abstract: The synthesis and characterization of oxidized bis-thioketal-trispiro dinitroxide biradicals that orient the nitroxides in a rigid, approximately orthogonal geometry are reported. The biradicals show better performance as polarizing agents in dynamic nuclear polarization (DNP) NMR experiments as compared to biradicals lacking the constrained geometry. In addition, the biradicals display improved solubility in aqueous media due to the presence of polar sulfoxides. The results suggest that the orientation of the radicals is not dramatically affected by the oxidation state of the sulfur atoms in the biradical, and we conclude that a biradical polarizing agent containing a mixture of oxidation states can be used for improved solubility without a loss in performance.
DOI: 10.1021/jo202349j
Authors: Eric L. Dane, Björn Corzilius, Egon Rizzato, Pierre Stocker, Thorsten Maly, Albert A. Smith, Robert G. Griffin, Olivier Ouari, Paul Tordo, Timothy M. Swager
Language: English
Subfield: Spectroscopy
Field: Chemistry
Open Access status: green
Awards: G1721210722, G3597886368, MIT/ Harvard Center for Magnetic Resonance, High Field DNP and EPR in Biological Systems, G7787715925, Molecules for Dynamic Nuclear Polarization and NMR Structure Determination
OpenAlex ID: W1584062542
FWCI: 5.226
Cites: 50
Cited by: 89
Related to: 10