Systems and Network Understanding of Cancer Stem Cells
Year: 2011
Type: book-chapter
Abstract: The notion that tumors arise from a rare population of cells with stem cell characteristics was first proposed more than a century ago when pathologists like Virchow and Cohnheim formulated the hypothesis that cancer results from the activation of embryonic-tissue remnants (Weiss 2000). Since then, advances in different fields have provided support to this original proposal that has led to the increasingly accepted yet controversial “cancer stem cell (CSC)” hypothesis that explains the development of multiple forms of human cancers (Wicha et al. 2006). The first experiments indicating the existence of these cells were performed in animal models in the 1970s where it was concluded that only a low percentage of transplanted murine lymphoma cells formed colonies in the spleen of recipient animals (Park et al. 1971a; Bruce and VAN DER 1963). Likewise, only a minimum number (1 in 100 to 1 in 100,000) of murine myeloma cells were able to form colonies in
DOI: 10.5772/18427
Authors: Asfar S. Azmi, Ramzi M. Mohammad, Sanjeev Banerjee, Zhiwei Wang, Bin Bao, Fazlul H. Sarkar
Language: English
Topic: Cancer Cells and Metastasis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1584488535