Year: 2001
Type: article
Abstract: : This paper illustrates some of the problems which can occur in any data set when clustering samples of gene expression profiles. These include a possible high degree of dependence of results on choice of clustering algorithm, further dependence of results on the choices of genes and samples to be included in the clustering (for example, whether or not to include control samples), and difficulty in assessing the validity of the grouping. We also demonstrate the use of Cox regression as a tool to identify genes influencing survival.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1584512145