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Vaccine Protection against a Heterologous, Non-Syncytium-Inducing, Primary Human Immunodeficiency Virus

Year: 1998

Type: article

Abstract: Vaccine-induced protection of chimpanzees against laboratory-adapted and syncytium-inducing, multiply passaged primary human immunodeficiency virus type 1 (HIV-1) isolates, but not against non-syncytium-inducing, minimally passaged ones, has been demonstrated. Following challenge with such an isolate, HIV-15016, we obtained complete protection in one of three chimpanzees previously protected against low- and high-dose HIV-1SF2 exposures after immunization with an adenovirus-HIV-1MN gp160 priming-HIV-1SF2 gp120 boosting regimen. At challenge, the protected chimpanzee exhibited broad humoral immunity, including neutralizing antibody activity. These results demonstrate the potential of this combination vaccine strategy and suggest that vaccine protection against an HIV isolate relevant to infection of people is feasible.

Source: Journal of Virology

DOI: 10.1128/jvi.72.12.10275-10280.1998

Authors: Marjorie Robert-Guroff, Harvinder Kaur, L. Jean Patterson, Michel Leno, Anthony J. Conley, Philip M. McKenna, Phillip D. Markham, Ersell Richardson, Kristine Aldrich, Kamalpreet Arora, Lalita Murty, Lucretia Carter, Susan Zolla-Pazner, Faruk Sinangil

Institutions: National Institutes of Health, National Cancer Institute, Advanced Bioscience Laboratories (United States), NYU Langone Health, New York University

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1584836554

FWCI: 1.879

Cites: 36

Cited by: 63

Related to: 10