Work

Formation, drug-release kinetics and solution-stability of N-acetyl-N-carboxymethyl chitosan nanoparticles as potential drug carriers

Year: 2013

Type: article

Abstract: Nano-aggregates of N-acetyl-N-carboxymethyl chitosan (NCac) were studied at 0.5 mg.mL -1 using pyrene fluorimetry analysis in 0.1 mol.L -1 phosphate buffer (pH 7.4). The size and morphology of the aggregates were determined by dynamic light scattering and atomic force microscopy. The stability of the particles for periods up to 20 h in buffer was determined. Camptothecin was entrapped in the particles using various methods and the rate constant for drug release (k) was determined. Lower k values indicate strong interactions between the drug and the hydrophobic core of the polymeric micelles.

Source: International Journal of Phytomedicine

Authors: Helen P. Bassani, Francine Valenga, Maria Rita Sierakowski, Rilton Alves de Freitas

Institution: Universidade Federal do Paraná

Language: English

Topic: Advanced Drug Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico

OpenAlex ID: W1585149689

FWCI:

Cites: 36

Cited by: 3

Related to: 10