Efectos del D-003 y el plicosanol sobre huesos de ratas ovariectomizadas
Year: 2008
Type: article
Abstract: D-003 is a mixture of higher aliphatic acids purified from sugarcane wax, whose main component is octacosanoicacid, an active metabolite from policosanol. Because of their structural and metabolic analogies, both substances have shownsimilar pharmacological effects, as inhibiting cholesterol synthesis by regulating the activity of hydroxymethyl glutaril CoAreductase, the key enzyme of this route, leading to cholesterol-lowering and antiosteoporotic effects, as well as to inhibit lipidperoxidation, an effect that also contributes to their antiosteoporotic effects. D-003, however, has shown to be more effectivethan policosanol as lipid-lowering and antioxidant agent, which suggests that it should have a greater antiosteoporotic potential,but no previous study had compared directly their effects on osteoporosis (OP) models. Therefore, the aim of this study was tocompare the effects of D-003 and policosanol on ovariectomized rats, the model that reproduces better the characteristic OP ofpostmenopausal women. Female SD rats were ovariectomized and distributed into four groups: one false-operated control, onepositive control and two treated with D-003 or policosanol, at 50 mg/kg, respectively. After three months on treatment, rats weresacrificed and their right femur and 5th lumbar vertebrae taken. Bone sections were decalcified and processed for assessing theeffects on the morphometric variables and bone resorption-formation markers. Both treatments prevented ovariectomy-inducedbone loss and increased bone resorption, since they prevented the reduction in the trabeculae number and thickness, and theinerease in trabecular gap and osteoclast number and perimeter compared with the positive control, without modifying theosteoblast surface, a bone formation surrogate. The effects of D-003 on all variables were superior to those of policosanol, thusconfirming the study hypothesis
Authors: Sarahí Mendoza, Miríam Noa, Rosa Más, Nilda Mendoza
Institution: Centro Nacional de Investigaciones Científicas
Language: Spanish
Subfield: Orthopedics and Sports Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W1585353396