Work

Osteosarcomas in transgenic mice expressing an alpha-amylase-SV40 T-antigen hybrid gene.

Year: 1990

Type: article

Abstract: Mice of a transgenic mouse lineage 501, produced by zygotic injection of the parotid alpha-amylase promoter-SV40 T-antigen hybrid gene, developed osteosarcomas at about 15 months of age. The tumors predominantly involved the axial skeleton, were sometimes multiple, and metastasized to the liver. A cell line derived from a primary tumor produced osteosarcomas on transfer to nude mice. The 501 transgenic lineage thus provides a valuable new model for studying the histogenesis of osteosarcomas.

Source: Europe PMC (PubMed Central)

Authors: B B Knowles, J McCarrick, N Fox, D Solter, I Damjanov

Institution: The Wistar Institute

Language: English

Topic: Sarcoma Diagnosis and Treatment

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute

Awards: T-CELL DIFFERENTIATION ROLE OF THYMIC STROMA, VIROLOGY AND GENETICS OF CANCER, Consolidated Basic Cancer Research Program