Thrombolysis With Intravenous Streptokinase Dose Not Alter 72-hours Mortality in Acute Myocardial Infarction
Year: 2012
Type: article
Study design: Observational Study
Abstract: Objective: a) To find out mortality in Acute Myocardial Infarction within 72-hours treatment in coronarycare unit b) To compare mortality in Acute Myocardial Infarction treated with intravenous Heparin to thatof intravenous streptokinase. Design: Observational, retrospective study Setting: Coronary care unit ofShaikh Zayed Postgraduate Medical Institute Lahore. Subject: Patient above >12 years of age, presentingwith acute myocardial infarction to Coronary Care Unit from 1.9.1989 to 31.8.1990 were included and theirmortality was compared with subsequent five years up to 31.8.1995. Intervention: Comparison ofintravenous Heparin 5000 units stat and 1000 units hourly infusion with 1,500,000 units of streptokinaseintravenous in 90 minutes in patients of Acute Myocardial Infarction along with other treatment given inboth groups. Main Outcome Measures: Death as a result of Acute Myocardial Infarction during 72-hoursstay at Coronary Care Unit. RESULTS: Baseline characteristics of two treatment groups were similar.Mortality rate with IV Heparin alone in 1989-90 were 2.3% (95% Cl, 0.07-4.57). With intravenousstreptokinase in 1990-91 4.0% (Cl 1.28-6.7, P>0.05) in 1991-92 2.8% (CI 0.59-5.01, P>0.05) in 1992-93 2.7%(Cl 0.09-5. 42, P>0.05) 1993-94 2.8% (Cl 0.59-8.54, P>0.05) in 1994-95 4.9% (Cl 1.37-8.54, P>0.05). Themortality was slightly increased during 1991-92 but change was not significant P>0.05. There was fall inmortality from 1993-95 again statistically insignificant P>0.05. CONCLUSION: Mortality rates in AcuteMyocardial Infarction remained same from 1989-90 to 1994-95. Thrombolysis with 1,500,000 units ofstreptokinase in acute myocardial infarction did not make any difference in mortality as compared tointravenous Heparin 5000 units stat and 1000 units/hourly within 72-hours of treatment at Coronary CareUnit.
Source: Pakistan Heart Journal
Authors: Muhammad Rashid, Arsa K. Butt
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W1585387082