Work

Replication protein A: directing traffic at the intersection of replication and repair

Year: 2010

Type: review

Abstract: Since the initial discovery of replication protein A (RPA) as a DNA replication factor, much progress has been made on elucidating critical roles for RPA in other DNA metabolic pathways. RPA has been shown to be required for DNA replication, DNA repair, DNA recombination, and the DNA damage response pathway with roles in checkpoint activation. This review summarizes the current understanding of RPA structure, phosphorylation and protein-protein interactions in mediating these DNA metabolic processes.

Source: Frontiers in bioscience

DOI: 10.2741/3652

Author: Greg, G. Oakley

Institution: University of Nebraska Medical Center

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: American Cancer Society, National Institute of General Medical Sciences, National Center for Research Resources

Awards: Novel Role of Base Excision Repair and Mismatch Repair in Cisplatin Sensitivity, G636203908, Nebraska Center for Cellular Signaling