Functional and Phenotypical Analysis of the Effects of Aging on B Cells and Their Bone Marrow Microenvironment
Year: 2010
Type: dissertation
Abstract: Aging impacts multiple organ systems, and specifically causes the immune system to lose its ability to efficiently fight off infections. Regarding immunity, aging research predominantly focuses on the adaptive immune system. B cells, which mediate the humoral arm of the adaptive immune system, develop throughout life in the bone marrow where microenvironmental `niches' are important. The bone marrow does not exactly `atrophy' with age; however, studies comparing young and old mice demonstrate an age-related change in the bone marrow B cell subpopulations. The overall goal was to determine if femoral and sternum bone marrow have different plasma cell composition and growth factor production that may affect antibody production and secretion. This study sought to determine the effects that age and cellular origin have on the bone marrow microenvironment. The conclusions drawn from this work will help expand the known mechanisms required for an efficient humoral response in the host.
Author: Nicole Ziegler
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1586051079