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Metabolic Syndrome and Physical Performance in Elderly Men: The Osteoporotic Fractures in Men Study

Year: 2011
Type: article
Abstract: OBJECTIVES: To examine the association between metabolic syndrome (MetS) and objective measures of physical performance. DESIGN: Cross-sectional analysis of the cohort study, the Osteoporotic Fractures in Men Study. SETTING: Six clinical sites in the United States. PARTICIPANTS: Five thousand four hundred fifty-seven ambulatory men (mean age 73.6 ± 5.9). MEASUREMENTS: Physical performance assessed according to grip strength, narrow walk speed, walking speed, and time to complete five repeated chair stands. Individual scores were converted to quintiles (worst=1 to best=5; unable to complete=0) and summed for an overall score (mean 11.6 ± 4.3, range, 1-20). MetS was defined according to World Health Organization criteria that include evidence of glucose dysregulation (insulin resistance, diabetes mellitus, or hyperinsulinemia) and at least two additional characteristics: high blood pressure, low high-density lipoprotein cholesterol, high triglycerides, obesity. RESULTS: More than one-quarter (26.3%) of participants met criteria for MetS. In separate linear regression models, four of five MetS components were related to performance (P<.001); only high blood pressure was unrelated. Men with MetS had a 1.1-point lower performance score (mean 10.8, 95% confidence interval (CI)=10.6-11.0) than men without MetS (mean 11.9, 95% CI=11.8-12.0) (P<.001), adjusting for age, race, education, and site. With further covariate adjustment, this difference was reduced but remained significant (β=-0.78, P<.001). A graded association was observed between number of MetS components (0, 1, 2, or ≥3) and performance (P for trend <.001). Findings were similar excluding men with diabetes mellitus or obese men. CONCLUSION: Metabolic dysregulation is related to objectively assessed poorer physical performance in relatively healthy older men.
DOI: 10.1111/j.1532-5415.2011.03518.x
Authors: Susan A. Everson‐Rose, Misti Paudel, Brent C. Taylor, Tien Dam, Peggy Mannen Cawthon, Erin LeBlanc, Elsa S. Strotmeyer, Jane A. Cauley, Marcia L. Stefanick, Elizabeth Barrett‐Connor, Kristine E. Ensrud
Institutions: University of Minnesota, Oregon Health & Science University, University of Pittsburgh, California Pacific Medical Center, University of California San Diego, Minneapolis VA Medical Center, Columbia University, Stanford University
Language: English
Field: Medicine
Open Access status: green
Awards: G1068966504, G1343274610, G1613471689, Osteoporotic Fractures in Men, G2576967755, G3049017749, G321186775, Osteoporotic Fractures in Men - MrOS Renewal, Osteoporotic Fractures in Men, Osteoporotic Fractures in Men - MrOS Renewal - Birmingham, Osteoporotic Fractures in Men - MrOS Renewal - Pittsburgh, Osteoporotic Fractures in Men (MrOS) - Administrative Center, Osteoporosis in Men, Osteoporotic Fractures in Men (MrOS) Renewal - Portland, Oregon Clinical and Translational Research Institute, Osteoporotic Fractures in Men (MrOS) - San Francisco Coordinating Center, G972017601
OpenAlex ID: W1586652035
FWCI: 0.762
Cites: 33
Cited by: 22
Related to: 10