Work

miR-155 releases the brakes on antitumor T cells

Year: 2015

Type: article

Abstract: cytokines are essential to support the expansion and function of tumor-specific T cells, but their effects are constrained by suppressor of cytokine signaling (SOCS) proteins as well as phosphoinositide and tyrosine-specific phosphatases. The microRNA miR-155 counteracts these inhibitory hurdles to potentiate intracellular cytokine signaling and T cell antitumor immunity.

Source: OncoImmunology

DOI: 10.1080/2162402x.2015.1026533

Authors: Yun Ji, Luca Gattinoni

Institutions: National Institutes of Health, National Cancer Institute, Center for Cancer Research

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913