Work

Reprogramming the tumor microenvironment: tumor-induced immunosuppressive factors paralyze T cells

Year: 2015

Type: review

Abstract: It has become evident that tumor-induced immuno-suppressive factors in the tumor microenvironment play a major role in suppressing normal functions of effector T cells. These factors serve as hurdles that limit the therapeutic potential of cancer immunotherapies. This review focuses on illustrating the molecular mechanisms of immunosuppression in the tumor microenvironment, including evasion of T-cell recognition, interference with T-cell trafficking, metabolism, and functions, induction of resistance to T-cell killing, and apoptosis of T cells. A better understanding of these mechanisms may help in the development of strategies to enhance the effectiveness of cancer immunotherapies.

Source: OncoImmunology

DOI: 10.1080/2162402x.2015.1016700

Authors: Annie A Wu, Virginia Drake, Huai-Shiuan Huang, ShihChi Chiu, Lei Zheng

Institutions: Johns Hopkins University, Johns Hopkins Medicine, University of Maryland, Baltimore, University of Maryland, College Park, National Taiwan University

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913