Work

Role of SOX family of transcription factors in central nervous system tumors.

Year: 2014

Type: article

Abstract: SOX genes are developmental regulators with functions in the instruction of cell fate and maintenance of progenitor's identity during embryogenesis. They play additional roles during tissue homeostasis and regeneration in adults particularly in the Central Nervous System (CNS). In the last years a growing number of evidences has shown that mutations and dysfunction of SOX factors are implicated in several human diseases, including a variety of cancers. In this review, we will summarize the current knowledge about SOX family in CNS tumors and their role in the origin and maintenance of the subpopulation of cancer stem cells in these tumors.

Source: Europe PMC (PubMed Central)

Authors: Arlet M Acanda de la Rocha, Nicolas Sampron, Marta M Alonso, Ander Matheu

Institutions: Clinica Universidad de Navarra, Biogipuzkoa Health Research Institute, Ikerbasque

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: European Commission, Deutsche Forschungsgemeinschaft, Eusko Jaurlaritza, Universidad de Navarra

Award: G3821285577