Genetic variants of adiponectin and risk of colorectal cancer
Year: 2014
Type: article
Abstract: Circulating adiponectin has been associated with lower risk of colorectal cancer (CRC). Genome-wide association studies have identified several single-nucleotide polymorphisms (SNPs) associated with adiponectin levels. However, it is unclear whether these SNPs are associated with CRC risk. In addition, previous data on SNPs in the adiponectin pathway and their associations with CRC are inconsistent. Therefore, we examined 19 SNPs in genes related to adiponectin or its receptors and their associations with CRC using logistic regression among 7,020 cases and 7,631 controls drawn from ten studies included in the Genetics and Epidemiology of Colorectal Cancer Consortium. Using data from a subset of two large cohort studies, we also assessed the contribution of individual SNPs and an adiponectin genetic score to plasma adiponectin after accounting for lifestyle factors among 2,217 women and 619 men. We did not find any statistically significant association between the 19 adiponectin-associated SNPs and CRC risk (multivariable-adjusted odds ratios ranged from 0.89 to 1.05, all p > 0.05). Each SNP explained less than 2.50% of the variance of plasma adiponectin, and the genetic score collectively accounted for 2.95 and 1.42% of the variability of adiponectin in women and men, respectively, after adjustment for age, body mass index, physical activity, smoking, alcohol consumption, regular use of aspirin or nonsteroidal anti-inflammatory drug and postmenopausal hormone use. In conclusion, our findings do not support an association between known adiponectin-related common SNPs and CRC incidence. However, known common SNPs account for only a limited proportion of the interindividual variance in circulating adiponectin. Further work is warranted to investigate the relationship between adiponectin and CRC while accounting for other components in the pathway.
Source: International Journal of Cancer
DOI: 10.1002/ijc.29360
Authors: Mingyang Song, Jian Gong, Edward L. Giovannucci, Sonja I. Berndt, Hermann Brenner, Jenny Chang‐Claude, Keith R. Curtis, Tabitha A. Harrison, Michael Hoffmeister, Li Hsu, Shuo Jiao, Loic Le Marchand, John D. Potter, Robert E. Schoen, Daniela Seminara, Martha L. Slattery, Emily White, Kana Wu, Shuji Ogino, Charles S. Fuchs, David J. Hunter, Shelley S. Tworoger, Frank B. Hu, Eric Rimm, Majken Jensen, Ulrike Peters, Andrew T. Chan
Institutions: Harvard University, Fred Hutch Cancer Center, Brigham and Women's Hospital, National Institutes of Health, Division of Cancer Epidemiology and Genetics, German Cancer Research Center, Deutsches Konsortium für Translationale Krebsforschung, University of Washington, University of Hawaii Cancer Center, Massey University, University of Pittsburgh Medical Center, National Cancer Institute, University of Utah, University of Utah Health Care, Dana-Farber Cancer Institute, Dana-Farber/Harvard Cancer Center, Massachusetts General Hospital
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Funders: Deutsche Forschungsgemeinschaft, National Institutes of Health, U.S. Public Health Service, Harvard Transdisciplinary Research in Energetics and Cancer Center, Harvard University, National Institute on Aging, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases
Awards: FHCRC High-Performance Computing Cluster, Dana Farber/ Harvard Cancer Center SPORE in Gastrointestinal Cancer, G133025269, G1464152897, G153510172, G1947136479, G2273349799, Diet, Activity, and Lifestyle as a Risk Factor for Colorectal Cancer, Nutritional and Biochemical/Genetic Markers of Cancer, G24053502, G2412562481, Biochemical Markers in the nurses' Health Study Cohort, G2757930255, Inflammation and Colorectal Neoplasia, Genome-Wide Association Study of Nonsynonymous SNPs in Colon Cancer, G3038867203, G3452152499, G3545534745, Detection of Colorectal Cancer Susceptibility Loci Using Genome-Wide Sequencing, G3614050419, Multiethnic Cohort Study of Diet and Cancer, Established Investigator Award Anti-Inflammatory Exposures in Cancer Prevention, Dietary and Hormonal Determinants of Cancer in Women, G412187901, G443607800, Genome Wide Association Coordinating Center, G459566519, Harvard Transdisciplinary Research in Energetics and Cancer Center, G5547620395, AROMATIC AMINES AND COLON CANCER RISK--GENETICS, G5624510383, Genetic Susceptibility to Cancer in Multiethnic Cohorts, JH/CIDR Genotyping for Genome-Wide Association Studies, G619791618, Mentored Patient-Oriented Research in Digestive Diseases, G673128162, G689520650, Molecular pathological epidemiology of colorectal cancer, Prospective Studies of Diet and Cancer in Men and Women, Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health Study, Biochemical Markers in the Nurses? Health Study Cohort, Cancer Epidemiology Cohort in Male Health Professionals, Molecular Epidemiology of Nutrition and Cancer in the Multiethnic Cohort Study, G8536616440, Cancer Center Support Grant, Genome-Wide Association Studies
OpenAlex ID: W1589037809