Frontotemporal anatomical connectivity and working‐relational memory performance predict everyday functioning in schizophrenia
Year: 2012
Type: article
Study design: Observational Study
Abstract: Hippocampal (relational memory) and prefrontal cortex (PFC; working memory) impairments have been found in patients with schizophrenia (SP), possibly due to a dysfunctional connection between structures. Neuroanatomical studies that describe reduced fractional anisotropy (FA) in the uncinate fasciculus support this idea. The dysconnection hypothesis in SP was investigated by examining frontotemporal anatomical connectivity (uncinate fasciculus FA) and PFC-hippocampal memory and their relationship with each other and everyday functioning. PFC-hippocampal memory was examined with two working-relational memory tasks: transverse patterning and a virtual Morris water task. SP exhibited a performance deficit on both tasks and had lower FA in bilateral uncinate fasciculus than healthy volunteers. Lower frontotemporal anatomical connectivity was related to lower working-relational memory performance, and both predicted worse everyday functioning.
Source: Psychophysiology
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Unified multivariate data-driven solutions for static and dynamic brain connectivity, Neural Mechanism of Schizophrenia: Use of Multiple Neuroimaging Tools to Examine, Multimodal Imaging of Neuropsychiatric Disorders (MIND): Mechanisms &, Multivariate methods for identifying multitask/multimodal brain imaging biomarkers
OpenAlex ID: W1589414598