Work

Insulin-Receptor Interaction in the Obese-Hyperglycemic Mouse

Year: 1973

Type: article

Abstract: The interaction of insulin with its receptor was studied in purified liver plasma membranes and isolated hepatocytes of the obese hyperglycemic mouse (ob/ob) and its thin litter mate.The ob/ob mouse is a genetic mutant characterized by marked obesity, hyperinsulinism, and resistance to both endogenous and exogenous insulin.Under identical condi-

Source: Journal of Biological Chemistry

DOI: 10.1016/s0021-9258(19)44468-2

Authors: C. Ronald Kahn, David M. Neville, Jesse Roth

Institutions: National Institutes of Health, National Institute of Mental Health

Language: English

Topic: Metabolism, Diabetes, and Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,430