Work

White matter integrity in traumatic brain injury: Effects of permissible fiber turning angle

Year: 2015

Type: conference-paper

Study design: Observational Study

Abstract: Traumatic brain injury (TBI) is the leading cause of death and disability in children. Diffusion weighted imaging (DWI) methods have been shown to be especially sensitive to white matter abnormalities in TBI. We used our newly developed autoMATE algorithm (automated multi-atlas tract extraction) to map altered WM integrity in TBI. Even so, tractography methods include a free parameter that limits the maximum permissible turning angles for extracted fibers, with little investigation of how this may affect statistical group comparisons. Here, we examined WM integrity calculated over a range of fiber turning angles to determine to what extent this parameter affects our ability to detect group differences. Fiber turning angle threshold has a subtle, but sometimes significant, effect on the differences we were able to detect between TBI and healthy children.

Source: IEEE International Symposium on Biomedical Imaging (ISBI)

DOI: 10.1109/isbi.2015.7164023

Authors: Emily L. Dennis, Yan Jin, Claudia Kernan, Talin Babikian, Richard Mink, Christopher Babbitt, Jeffrey Johnson, Christopher C. Giza, Robert F. Asarnow, Paul M. Thompson

Institutions: University of Southern California, University of California, Los Angeles, The Lundquist Institute, UCLA Medical Center, Harbor–UCLA Medical Center, Miller Children's & Women's Hospital, LAC+USC Medical Center, Mattel Children's Hospital

Language: English

Topic: Advanced Neuroimaging Techniques and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute on Aging, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: Reconnection of Neural Networks and Cognitive Recovery after Pediatric TBI, Using glutamatergic pharmacotherapy to optimize TBI recovery, HARDI Mapping of Disease Effects on the Brain, Alzheimer's disease risk analyzed using population imaging genomics, Longitudinal Tracking of Traumatic Brain Injury: Advanced Connectomics, ENIGMA Center for Worldwide Medicine, Imaging & Genomics, Laboratory of Neuro Imaging Resource (LONIR), Predicting Brain Changes in HIV/AIDS

OpenAlex ID: W1589922718

FWCI: 5.712

Cites: 8

Cited by: 8

Related to: 10