Investigating drug classes in biomedical terminologies from the perspective of clinical decision support.
Year: 2010
Type: conference-paper
Abstract: OBJECTIVES: To assess whether 1) the necessary drug classes and 2) the necessary drug-class membership relations are represented in biomedical terminologies in order to support clinical decision regarding drug-drug interactions. METHODS: In order to investigate drug classes and drug-class membership in clinical terminologies, we start by establishing a reference list of these entities. Then, we map drugs and classes to the UMLS, where we investigate their relations. RESULTS: 186 (83%) of the 223 names for drug classes mapped to the UMLS. The single best source is SNOMED CT with 75%. 140 (89%) of the 157 drug-membership relations were found in the UMLS. CONCLUSIONS: One important category of drug classes missing from all clinical terminologies is related to drug metabolism by the Cytochrome P450 enzyme family.
Source: PubMed
Authors: Olivier Bodenreider, Dina Demner Fushman
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1589958766