Plants used in the management of diabetic complications.
Year: 2014
Type: article
Abstract: Diabetes is a disease, which has assumed vital public health importance because of the complications associated with it. Various mechanisms including polyol pathway along with a complex integrating paradigm have been implicated in glucose-mediated complications. Though polyol pathway was established as a major mechanism, precise pathogenesis of these complications is not yet completely elucidated. Thus research focus was shifted towards key enzyme, aldose reductase in the pathway. Even though various compounds with aldose reductase inhibitory activity were synthesised, a very few compounds are under clinical use. However, studies on these compounds were always under conflicting results and an attempt has been made to review various natural substances with aldose reductase inhibitory activity and their role in management of diabetic complications.
Source: Europe PMC (PubMed Central)
Authors: D Dodda, V Ciddi
Institution: Kakatiya University
Language: English
Topic: Aldose Reductase and Taurine
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1591119504