Year: 2014
Type: article
Abstract: Pathogenic species of Candida differ in many aspects, including their clinical prevalence, virulence, and profile of antifungal resistance. One of the causes of these differences is possibly related to the differential capacity of these species to deal with oxidative stress. In this study, we compared clinical isolates of eight species of Candida with respect to their oxidative stress resistance in vitro, oxidative damage induc-tion, and antioxidant enzymes. Intraspecific and interspecific variation was observed. In accord with data previously obtained from laboratory isolates, the results here indicate that C. albicans, C. glabrata and C. krusei have a more effective antioxidant system, and that C. dubliniensis, C. famata and C. guilliermondii are highly sensitive to oxidative stress. C. parapsilosis andC. tropicalis have intermediate resistance profiles. The stronger antioxidant system of some species may enable them to cause systemic infections or to resist antifungals.
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1591462170