Work

Incubation of Fear

Year: 2013

Type: article

Abstract: While fear and anxiety can grow over time in anxiety disorders, most efforts to model this phenomenon with fear conditioning in rodents cause fear that remains stable or decreases across weeks or months. Here, we describe several methods to induce conditioned fear that grows over the course of 1 month and is sustained for at least 2 months using an extended fear conditioning approach. These methods include a very reliable standard method that causes multiple fear measures to increase over months, as well as alternative methods.

Source: Current Protocols in Neuroscience

DOI: 10.1002/0471142301.ns0627s64

Authors: Charles L. Pickens, Sam A. Golden, Sunila G. Nair

Institutions: Kansas State University, Icahn School of Medicine at Mount Sinai, University of Washington

Language: English

Topic: Memory and Neural Mechanisms

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute on Drug Abuse

Award: G1997962874