Work

Potent inhibitory effect of the cyclolignan picropodophyllin (PPP) on human adrenocortical carcinoma cells proliferation.

Year: 2011

Type: article

Abstract: Adrenocortical carcinoma (ACC) is a very aggressive tumor with a poor prognosis. Available treatments for this type of cancer are far from being satisfactory. The IGF signalling pathway represents an important mechanism for ACT growth and constitutes a relevant therapeutic target. We investigated the effect of picropodophyllin (PPP), a member of the cyclolignan family and a new inhibitor of IGF-1R, on proliferation of human adrenocortical cell lines H295R and SW-13. PPP inhibits proliferation and induces an important accumulation in G2/M phase and apoptosis of H295R and SW-13 cells. Our data suggest that PPP may be a promising candidate for drug development for adrenocortical carcinoma.

Source: Europe PMC (PubMed Central)

Authors: Mabrouka Doghman, Magnus Axelson, Enzo Lalli

Institutions: Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, Université Nice Sophia Antipolis

Language: English

Topic: Plant-derived Lignans Synthesis and Bioactivity

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1592298195

FWCI: 0.535

Cites: 22

Cited by: 12

Related to: 10