Work

Replacement of Loop II of VP1 of the DA Strain with Loop II of the GDVII Strain of Theiler’s Murine Encephalomyelitis Virus Alters Neurovirulence, Viral Persistence, and Demyelination

Year: 1998

Type: article

Abstract: Theiler's murine encephalomyelitis viruses, which are murine picornaviruses, can cause central nervous system inflammatory disease. To study the role of loop II in capsid protein VP1, two mutant viruses of strain DA in which DA loop II amino acids were replaced with strain GDVII amino acids were constructed. Infection of mice with the two mutant viruses led to dramatically different patterns of disease.

Source: Journal of Virology

DOI: 10.1128/jvi.72.9.7557-7562.1998

Authors: Yoshiaki Wada, Ingeborg J. McCright, Frank G. Whitby, Ikuo Tsunoda, Robert S. Fujinami

Institution: University of Utah

Language: English

Topic: Viral Infections and Immunology Research

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Institute of Neurological Disorders and Stroke