The inhibitors of substrate-incorporation in tumor cells. III. An investigation on the biological activities of renastacarcin.
Year: 1977
Type: article
Abstract: The purified sample of renastacarcin was tested against various kinds of Gram-positive and -negative bacteria, yeast and fungi.As a result, it was concluded that this compounds was almost devoid of antimicrobial activity even at a concentration of 200 mcg/ml.However, renastacarcin showed a significant antitumor activity both in vitro and in vivo against ascitic type of Ehrlich carcinoma and Sarcoma 180 in mice.When the tumor cells were incubated with renastacarcin, the lysis of cell membrane and subsequent leakage of the cellular contents were observed by means of the optical and microscopical method.The LD50 values of renastacarcin in mice were observed to be 40mg/kg intraperitoneally, and 23.5mg/kg intervenously.
Authors: Tetsuo SASAKI, Noboru OTAKE, Hiroshi YONEHARA, Akio KOBAYASHI, Hideaki FUKAWA
Institutions: The University of Tokyo, Nisshin Flour Milling Inc. (Japan)
Language: English
Subfield: Toxicology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W1593312083