Work

Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments

Year: 2011

Type: article

Abstract: Microfluidic devices allow for precise control of the cellular and noncellular microenvironment at physiologically relevant length- and time-scales. These devices have been shown to mimic the complex in vivo microenvironment better than conventional in vitro assays, and allow real-time monitoring of homotypic or heterotypic cellular interactions. Microfluidic culture platforms enable new assay designs for culturing multiple different cell populations and∕or tissue specimens under controlled user-defined conditions. Applications include fundamental studies of cell population behaviors, high-throughput drug screening, and tissue engineering. In this review, we summarize recent developments in this field along with studies of heterotypic cell-cell interactions and tissue specimen culture in microfluidic devices from our own laboratory.

Source: Biomicrofluidics

DOI: 10.1063/1.3553237

Authors: Ioannis K. Zervantonakis, Chandrasekhar R. Kothapalli, Seok Chung, Ryo Sudo, Roger D. Kamm

Institutions: Massachusetts Institute of Technology, Korea University, Keio University

Language: English

Topic: 3D Printing in Biomedical Research

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: bronze

Funders: National Science Foundation, National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering

Awards: G1306074373, EFRI-CBE: A Multifaceted Approach to the Modeling of Angiogenesis, Self-Assembling Peptides for Tissue Engineering