Work

Tight Junction in Blood‐Brain Barrier: An Overview of Structure, Regulation, and Regulator Substances

Year: 2012

Type: review

Abstract: Blood-brain barrier (BBB) is a dynamic interference that regulates the nutrition and toxic substance in and out of the central nervous system (CNS), and plays a crucial role in maintaining a stable circumstance of the CNS. Tight junctions among adjacent cells form the basic structure of BBB to limiting paracellular permeability. In the present review, the constituents of tight junction proteins are depicted in detail, together with the regulation of tight junction under stimulation and in pathological conditions. Tight junction modulators are also discussed.

Source: CNS Neuroscience & Therapeutics

DOI: 10.1111/j.1755-5949.2012.00340.x

Authors: Wei‐Ye Liu, Zhi‐Bin Wang, Li‐Chao Zhang, Xin Wei, Ling Li

Institutions: Second Military Medical University, Seventh People's Hospital of Shanghai

Language: English

Topic: Barrier Structure and Function Studies

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Natural Science Foundation of China