Recombinant Human Thyrotropin as an Adjuvant to Radioiodine Therapy for Nontoxic, Nodulal Goiter.
Year: 2005
Type: dissertation
Abstract: In this thesis the use of recombinant human thyrotropin (rhTSH) as a possible adjunct to radioiodine therapy for thyroid volume reduction in patients with nontoxic, nodular goiter is explored.This first chapter reviews the clinical manifestations, diagnostic evaluation and treatment (by thyroidectomy, L-thyroxine or radioiodine) of nontoxic, nodular goiter.Next, an introduction to the hormone thyrotropin (thyroid stimulating hormone, TSH) is given and thereafter we focus on the development of rhTSH for use in humans, particularly in patients with differentiated thyroid cancer. Nontoxic, Nodular Goiter1.1.1 1 .1 1 .2 1 .228 General Introduction and Outline of the ThesisRecently the effect of 0.9 mg rhTSH on thyroid size was studied in 9 male healthy euthyroid individuals (89).Thyroid volume was measured by ultrasonography at baseline and 4 h and 1, 2, 4, 7 and 28 days after the administration of 0.9 mg rhTSH.Twenty-four hours after rhTSH administration thyroid volume was 1 .
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1595087607