Work

The power of interval mapping of quantitative trait loci, using selected sib pairs.

Year: 1994

Type: article

Abstract: The interval-mapping procedure of Fulker and Cardon for analysis of a quantitative-trait loci (QTL) is extended for application to selected samples of sib pairs. Phenotypic selection of sib pairs, which is known to yield striking increases in power when a single marker is used, provides further increases in power when the interval-mapping approach is used. The greatest benefits of the combined approach are apparent with coarse maps, where QTLs of relatively modest (15%-20%) heritability can be detected with widely spaced markers (40-60 cM apart) in reasonably sized sibling samples. Useful information concerning QTL location is afforded by interval mapping in both selected and unselected samples.

Source: PubMed Central

Authors: L R Cardon, D W Fulker

Institution: Stanford University

Language: English

Topic: Genetic Mapping and Diversity in Plants and Animals

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institute on Drug Abuse, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: DIFFERENTIAL DIAGNOSIS IN READING DISABILITY, BEHAVIORAL GENETIC STUDIES OF DRUG ABUSE VULNERABILITY, Differential Diagnosis in Learning Disabilities

OpenAlex ID: W1595609022

FWCI: 3.425

Cites: 9

Cited by: 87

Related to: 10